Pharmacists and Community Health Workers (CHWs) are embedded in the community and part of the nation’s critical frontline workforce in the ongoing public health response to COVID-19. Policymakers and health care leaders are calling for the rapid scale-up and integration of CHWs to strengthen COVID-19 prevention plans and address longstanding inequities. Pharmacists are needed because they play a unique role at the local level to address vaccine hesitancy, ensure equitable distribution and access. These trusted messengers are central to reaching vulnerable communities and addressing determinants of poor health, which have been exacerbated by the pandemic.